Medical Devices
The Chief Medical Officer, Sir Liam Donaldson and the All Party Parliamentary Thrombosis Group are today holding a leadership summit on venous thromboembolism (VTE) in the NHS. Health Minister, Ann Keen, the All Party Chair, John Smith MP, and NHS Medical Director, Sir Bruce Keogh are among the speakers at event to raise awareness of the Department of Health"s prevention strategy for VTE. NHS senior managers will learn of the comprehensive and important drive to save lives from this important cause of avoidable death.
Evidence suggests that outcomes in many clinical settings leave a lot to be desired, which means that research into quality improvement (QI) in clinical care has the potential to greatly improve the lot of patients. Now a study in the journal Medical Care Research and Review published by SAGE suggests that both theoretical and practical improvements in QI effectiveness studies could make these into much more powerful tools for positive change.
Some patient advocates are lobbying to legalize "compassionate use" of experimental drugs for people with terminal illnesses who have exhausted other treatments, prompting a debate about how and when to provide such patients with treatments that could prolong their lives, the New York Times reports. Most insurers do not cover unproven treatments, and physicians have concerns that using experimental treatment could give patients false hope and cause unnecessary pain. Drugmakers are concerned that if there are unfavorable outcomes from providing patients with an unproven treatment, it could hurt the drug"s chances of receiving FDA approval. At the same time, FDA does not want to grant drugs and their makers the opportunity to skip clinical trials. Currently, patients must individually apply to receive treatments through compassionate use (Harmon, New York Times, 5/17).
A highly successful and innovative training program that prepares chief residents at medical schools to diagnose and treat health problems common to older adults -- and to prepare the medical students and residents who they help train to do the same -- will include three additional medical schools, the Association of Directors of Geriatric Academic Programs (ADGAP) has announced.
U.S. Marshals, at the request of the Food and Drug Administration, today seized drug products manufactured by Caraco Pharmaceutical Laboratories Ltd. (Caraco), at the company"s Michigan facilities in Detroit, Farmington Hills, and Wixom. The seizure also includes ingredients held at these same facilities. "The FDA is committed to taking enforcement action against firms that do not manufacture drugs in accordance with our good manufacturing practice requirements," said Janet Woodcock, M.D., director of the FDA"s Center for Drug Evaluation and Research. "Compliance with these standards prevents harm to the public."
Some Senators "struggled" Wednesday with the possibility that the health reform overhaul could derail America"s tradition of employer insurance plans, The New York Times reports.
The Senate Commerce Committee has found that a flawed payment database produced by a UnitedHealth subsidiary and distributed to other major insurance companies has led insurers to underpay millions of out-of-network claims, forcing patients to make up the difference of health care providers" fees, the Wall Street Journal reports. Aetna, Cigna, WellPoint, and other large insurers used the data to calculate their "reasonable and customary" charges. They also provided UnitedHealth"s subsidiary, Ingenix, with historic data about their payments, which became the foundation of ongoing versions of the flawed payment models.
A Lifeline For Primary Care The New England Journal of Medicine
The Massachusetts Department of Public Health yesterday issued a directive recommending that health care providers include written consent for HIV testing in the general permission forms given to patients receiving medical care, the Boston Globe reports. State health care providers typically give patients separate consent forms for HIV testing, a practice health officials say poses as a barrier to HIV testing for patients and their providers. The new Massachusetts recommendation states that HIV testing should be explicitly mentioned on standard general consent forms. Reinforcing a provision in the CDC"s 2006 HIV testing guidelines, the directive also recommends routine HIV testing for all residents age 13 to 64 in health care settings. Patients in Massachusetts must still opt in to HIV testing, whereas the CDC recommends that HIV testing be performed unless a patient opts out, according to the Globe (Cooney, Boston Globe, 6/25).
The world is slowly losing the fight against hunger in the Horn of Africa, according to the International Federation of Red Cross and Red Crescent Societies (IFRC), which renewed its call for emergency food supplies, water and recovery activities to help about 2.5 million food insecure people in Djibouti, Ethiopia, Kenya and Somalia, Xinhua/CRIENGLISH.com reports. The IFRC"s revised emergency appeal seeks $67 million to assist 2.5 million people over five years.
The Healthcare Association of New York State (HANYS) has awarded its ninth annual Pinnacle Award for Quality and Patient Safety to NewYork-Presbyterian Hospital, Winthrop-University Hospital, St. Mary"s Hospital at Amsterdam, and Stony Brook University Medical Center for their efforts in developing and implementing initiatives to improve care in each facility.
Cirrhosis is a world wide, bad prognosis liver disease and characterized by excessive collagen deposition and liver function damage. In our previous work, p90RSK is observed significantly up-regulated in association with elevated collagen type I levels in rat liver fibrosis. But detail mechanism of this phenomenon is still unknown.
With the caloric needs of the planet expected to soar by 50 percent in the next 40 years, planning and investment in global agriculture will become critically important, according a new report released recently.
UCB announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) has issued a positive opinion recommending that the European Commission grants a marketing authorisation for Cimzia® (certolizumab pegol), in combination with methotrexate (MTX), for the treatment of moderate to severe active rheumatoid arthritis in adult patients when the response to disease-modifying anti-rheumatic drugs (DMARDs) including MTX, has been inadequate. In these patients, Cimzia® can be given as monotherapy in case of intolerance to MTX or when continued treatment with MTX is inappropriate. Cimzia® has been shown to reduce the rate of progression of joint damage as measured by X-ray and to improve physical function, when given in combination with MTX.
Condom vending machines will be unveiled on Monday in Dar es Salaam, Tanzania, as part of a six-year pilot HIV prevention initiative in the country, Tanzania"s The Citizen reports. Daniel Crapper of Population Services International said, "We are working very hard to ensure that condoms are widely available to the people." About 100 machines -- at a cost of about 380,000 Kenyan shillings, or $350 -- will be installed in various bars in Dar es Salaam. The project also will be carried out in Morogoro, Iringa and Mbeya before being rolled out to other regions across the country, according to Crapper. "Bars and night clubs are in our targets because they have the highest risk of unsafe sex, especially when people get drunk," Crapper said, adding, "This will enable condoms to be available almost daily." He noted that the condoms will be offered at a lower cost compared with some retail outlets and that the new initiative will not interfere with condom distribution systems throughout the country. According to The Citizen, the condoms will be available for purchase from the vending machines for 100 shillings, or about $1. John Wanyancha, PSI"s HIV/AIDS program manager, said that the project"s leaders focused on targeting areas with high HIV/AIDS rates after research revealed that inaccessibility to condoms at night was a major challenge in efforts to curb the spread of the disease. He noted that about 324 million condoms have been distributed in Tanzania since 2001 (Mbani, The Citizen, 5/15).
The drug, called olaparib, specifically targets hereditary cancer caused by faulty BRCA1 and BRCA2 genes. The small scale patient trial has shown remarkable benefit for patients with breast, ovarian and prostate cancer.
The recent decline in invasive breast cancer in the US was significantly less pronounced in the poor and those who live in rural areas. Researchers writing in the open access journal BMC Medicine suggest this may be due to varying reductions in the numbers of women taking hormone therapy (HT).
The widely used antidepressant and pain medication amitriptyline--but not other closely related drugs -- can impersonate the brain"s own growth factors, researchers at Emory University School of Medicine have shown.
The University of Texas Health Science Center at Houston has received a $412,500 federal stimulus grant for Parkinson"s disease research, the university announced today. It is the university"s first federal stimulus grant.
The AGA Foundation for Digestive Health and Nutrition (FDHN) has named Michael Y. Choi , MD, the first recipient of the Mary Terese Hartzheim Award for Neuroendocrine Tumor Research. This new research award was created for young investigators interested in researching carcinoid or neuroendocrine tumors. Dr. Choi is an investigator at Massachusetts General Hospital and an instructor of medicine at Harvard Medical School, Boston. He was previously named an AGA Foundation Research Scholar Award recipient in 2005.
German pain expert company GrÃønenthal GmbH announces that the new centrally acting analgesic tapentadol is now available in the United States. The drug is indicated for the relief of moderate to severe acute pain in patients 18 years of age and older. Approval was given by the US Food and Drug Administration (FDA) in November 2008 for tapentadol (NUCYNTATM) tablets. With the cooperation of GrÃønenthal and its marketing partner Ortho-McNeil-Janssen Pharmaceuticals, Inc., the medication can now be prescribed by physicians and other appropriate health care professionals in the United States.
Joining a prestigious group including Anish Kapoor and Bernardo Bertolucci, acclaimed Shakespearean actor Simon Russell Beale was welcomed as an Honorary Fellow of the Institute of Psychoanalysis at a presentation on Sunday 21 June 2009. The award was made in recognition of Russell Beale"s "contribution to psychoanalysis through his exceptionally thoughtful work as an actor, especially in major Shakespearean roles and through his reflections on them."
An article published Online First and in this week"s edition of reports information about Golimumab, a new tumour necrosis factor-í± (TNF-í±) inhibitor. It reduces the signs and symptoms of rheumatoid arthritis in patients who have previously received any other TNF-í± inhibitor. This drug might be a good alternative for patients who have inadequate responses to one or two other TNF-í± inhibitors.
With triple digit temperatures expected over the weekend and into early next week, Cal/OSHA urges employers to observe the precautions specified in the heat illness prevention regulation. To ensure compliance Cal/OSHA will have teams of investigators inspecting outdoor employers over the weekend for heat illness prevention requirements. For employees working outdoors, the hot sun with high temperatures can be life-threatening.
New York"s Empire State Stem Cell Board earlier this month decided to allow embryonic stem cell researchers who receive state funding to compensate women for donating their eggs for use in research, making New York the first state to enact such a policy, the Washington Post reports (Stein, Washington Post, 6/26). According to the New York Times, the New York state Legislature in 2007 allotted $600 million for an 11-year stem cell research plan (Nelson, New York Times, 6/26). Under the board"s decisions, researchers receiving the state funding may pay women up to $10,000 to compensate them for the time, discomfort and expenses associated with egg donation. David Hohn, vice chair of the board"s two committees that endorsed the decision, said that the board "could not distinguish ethically between the payment for in vitro fertilization, which is very well precedented, and the compensation for donation for research." The board said researchers should follow the same guidelines as infertility clinics that receive donated eggs for infertile couples. Under those guidelines, payments exceeding $5,000 must be justified, and those exceeding $10,000 are considered excessive (Washington Post, 6/26). Robert Klitzman, director of the master"s degree program in bioethics at Columbia University and a member of the stem cell board"s ethics committee, said the payments will be carefully evaluated by an institutional review board (New York Times, 6/26).The Post reports that the decision goes against policies in other states that offer funding for embryonic stem cell research, as well as against current guidelines from scientific organizations like the National Academy of Sciences (Washington Post, 6/26). NAS guidelines, for example, prohibit paying women for eggs used in stem cell research. Similarly, the internal guidelines for New York-based groups like Rockefeller University, Cornell University and the Sloan-Kettering Institute prohibit financial compensation for donated eggs. However, researchers say that efforts to recruit unpaid donors have been unsuccessful and that the board"s decision will give New York an advantage in stem cell research (New York Times, 6/26). The decision was welcomed by scientists and other proponents of stem cell research, who said it will allow them to further research in areas like therapeutic cloning. The process, also known as somatic cell nuclear transfer, involves replacing the genetic material in a human egg with genes from the nucleus of a patient"s cell. The egg is then developed into an early embryo, which, in theory, could be used to produce stem cells that the patient"s immune system would not reject. Although the procedure has been unsuccessful so far, researchers say the board"s decision will help attract more donors, which will allow for more experiments. Egg donation involves weeks of hormone injections to stimulate the ovaries and a painful egg extraction procedure, which carries rare but serious risks. Other attempts at soliciting women to donate eggs for stem cell research have been unsuccessful, according to the Post.Some critics of the board"s decision said that paying women for eggs could lead to exploitation, especially for low-income women. Thomas Berg -- a Roman Catholic priest who is director of the Westchester Institute for Ethics and the Human Person and a member of the Empire State Stem Cell Board"s ethics committee -- said that in the current economic recession, paying a woman $10,000 to participate in a research project is an "undue inducement." He added that he thinks it "manipulates women" and "creates a trafficking in human body parts." Other opponents of the decision questioned if compensating women who donate eggs for research is indeed equivalent to the process for infertility treatments. Jonathan Moreno, a professor of bioethics at the University of Pennsylvania, said that donors recognize that egg donation for infertility treatments is a "very concrete good for society" but that "you can"t be sure any biological material you collect for research wi
Women who have depression symptoms prior to becoming pregnant are at an increased risk for having preterm births, with the risk twice as high for black women as for white women, according to a study in the Journal of Women"s Health, Reuters reports. For the study, Amelia Gavin of the University of Washington and colleagues examined the links between race, preterm birth and pre-pregnancy depressive mood among 555 women. The study used data collected from 1990-1996 as part of a larger, long-term investigation of heart disease risk.Researchers determined that 18.1% of the 249 black women in the study gave birth prior to 37 weeks" gestation, compared with 8.5% of the 306 white women in the study. The study also found that 9.4% of black women had pre-pregnancy symptoms of depressive mood, compared with 7.2% of white women. After researchers accounted for other factors associated with preterm birth, such as body weight and sociodemographic characteristics, black women"s risk remained more than twice that of white women.Gavin said, "The black-white disparity in preterm birth may be in part a consequence of different exposures to depressive mood prior to pregnancy." She said, "Reproductive outcomes must be viewed in light of women"s health over the entire life-course, as well as during pregnancy," adding that the study"s results suggest that "the experience of cumulative health disadvantages or "weathering"" might play a role in increased risk for preterm birth (Hendry, Reuters, 6/25).
NPR began a series of reports on the health care lobbyists who attend Congressional sessions as part of their campaign. Richard Miller, a "longtime lobbyist for the American Chiropractic Association, says it"s important that the chiropractors keep on top of the health care overhaul legislation - and also take pains to make sure that senators and staff see them doing that, because the chiropractors are small dogs in a big fight." President Barack Obama "certainly sees Washington"s lobbyists as an obstacle to change. He"s tried limiting their access to the executive branch, but that runs into the constitutional question." Lobbying is on the rise: "Between 1998 and 2008, the number of registered lobbyists on health care more than doubled, to 3,627, according to the Center for Responsive Politics." Spending also increased: "Organizations lobbying on health care spent $484.4 million in 2008, more than two and a half times the spending in 1998." The project includes an interactive panoramic photo of lobbyists in the Senate HELP Committee hearing room and asks readers to help identify the players (Overby and Seabrook, 6/25).
USAID announced on Thursday a $1 million commitment to a Red Cross project aimed at helping those "living along southern Africa"s Zambezi River cope with worsening natural disasters because of climate change," the AP/Washington Post reports.
There have been 19 new cases of HIV diagnosed in Montana since the beginning of the year, whereas the state usually has an average of about 20 newly diagnosed cases annually, according to a recent report by the state Department of Public Health and Human Services, the AP/KXNet.com reports (AP/KXNet.com, 6/25). Anna Whiting Sorrell, director of the agency, said that reaching 19 cases before the end of June suggests that people might be increasingly putting themselves at risk. Montana STD/HIV Section Supervisor Laurie Kops, said, "It"s just a little bit alarming to us that we"ve got those numbers, but it"s not that we don"t expect those numbers because we think that there are folks out there who don"t know what their status is." Officials are recommending residents be tested on Saturday as part of National HIV Testing Day (Montana"s News Station.com, 6/25).
A clinical trial of masitinib, a drug in development for the treatment of rheumatoid arthritis, has shown it to be well tolerated and effective. Researchers writing in BioMed Central"s open access journal Arthritis Research and Therapy have shown that treatment with masitinib significantly reduced the severity of active arthritis.
The menopause marks the time in a woman"s life when her menstruation stops and she is no longer fertile (able to become pregnant). In the UK the average age for the menopause is 52 (National Health Service), while in the USA it is 51 (National Institute of Aging). About one fifth of women in India experience menopause before the age of 41, a study found. The menopause is a normal part of like - it is a milestone, just like puberty - it is not a disease or a condition. Even though it is the time of the woman"s last period symptoms may begin many years earlier. Some women may experience symptoms for months or years afterwards.
The Multiple Myeloma Research Foundation (MMRF) has announced a collaboration with the Broad Institute of MIT and Harvard to systematically uncover the molecular changes underlying multiple myeloma by whole genome sequencing of individual patient tumors. The MMRF will provide both patient samples for analysis as well as funding for the project. All data from this collaboration will be put in the public domain.
Kidney transplant patients have a weaker response to influenza immunization than healthy individuals, especially in the first six months after receiving a transplant, according to a study published in the July issue of the American Journal of Kidney Diseases, the official journal of the National Kidney Foundation.
The American Public Health Association (APHA) applauds the House for today passing a comprehensive climate change bill that includes important provisions to protect the health of the public.
A nationwide public opinion poll conducted by Hamilton Lock for the British Medical Association released has revealed how worried the public is about future funding of the health service in light of the recession.
The University of Queensland has produced the first Australian batch of a new candidate vaccine against the H1N1 "swine flu" virus.
Radiant Research, Inc. announced that it is actively recruiting subjects and establishing operational plans for upcoming H1N1 vaccine trials. The World Health Organization declared the H1N1 influenza outbreak a pandemic, and the CDC has shipped virus samples to several manufacturers with the hope of having vaccine available to the general public by the fall. Manufacturers will need to complete clinical trials prior to release of vaccine to the public.
Gilead Sciences, Inc. (Nasdaq:GILD) announced that the Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency, has adopted a positive opinion on the company"s Marketing Authorisation Application for aztreonam lysine 75 mg powder and solvent for nebuliser solution (aztreonam lysine) for the suppressive therapy of chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis (CF) aged 18 years and older. The opinion is for conditional approval, contingent on the successful completion of an ongoing study.
Diabetes patients who are hospitalized for non-critical illnesses, and develop hypoglycemia while hospitalized, are likely to remain hospitalized longer and face greater risk of mortality both during and after hospitalization, according to a study published in the July issue of Diabetes Care.
Diabetes UK is asking you to donate your unwanted or broken jewellery and accessories to our jewellery appeal.
The European Medicines Agency (EMEA) has today announced their recommendation to withdraw the marketing authorisations for dextropropoxyphene-containing medicines (including co-proxamol) across the European Union (EU). This recommendation was made after the Committee on Medicinal Products for Human Use (CHMP) concluded that the risks, particularly of potentially fatal overdose, were greater than the medicine"s benefits. The EMEA"s recommendation has been forwarded to the European Commission (EC) for a decision which will be legally binding across the EU. In the UK, the only medicine affected by the EMEA"s announcement is co-proxamol.
The Health and Safety Executive (HSE) is urging landlords and property agents to ensure that their gas appliances are serviced and maintained and that landlords" gas safety checks are completed. It follows the prosecution of a Tamworth man, after four people were taken to hospital suffering suspected carbon monoxide poisoning at a rented property.
The expression and activity of Cystathionase is reduced in rodent models of liver injury, leading to hyper-homocysteinemia and impaired generation of hydrogen sulphide, two factors that contribute to endothelial dysfunction and increased intrahepatic resistance.
IDF, WHF and UICC join forces
MVP® (Managed Ventricular Pacing), exclusive programming on Medtronic pacemakers, which is proven to be effective in reducing unnecessary pacing in pacemaker patients, was applied in the MVP Trial of implantable cardioverter-defibrillator (ICD) patients. Data from MVP trial, sponsored by Medtronic, Inc. (NYSE: MDT), were presented today as a late breaking clinical trial at Heart Rhythm 2009, the annual scientific sessions of the Heart Rhythm Society.
MedImmune continues to advance its commitment to pediatric research with today"s announcement of the first observational prospective study designed to assess the burden of respiratory syncytial virus (RSV) among preterm infants 32-to-35 weeks gestational age (GA) in outpatient settings during their first year of life.
Sosei Group Corporation ("Sosei"; TSE Mothers Index: 4565) and Vectura Group plc ("Vectura"; LSE: VEC) announce the commencement of a Phase III clinical study by Novartis, with NVA237, a once-daily, long-acting muscarinic antagonist (LAMA) for the treatment of chronic obstructive pulmonary disease (COPD). NVA237 is a dry powder formulation for oral inhalation of glycopyrronium bromide, a LAMA with a rapid onset of activity. The study has now appeared on clinicaltrials.gov and will be recruiting in the next few weeks when the first patient first visit will trigger a $7.5 million milestone payment to both Sosei and Vectura.
Hereditary angioedema (HAE) is an autosomal dominant disease affecting between 4,000 and 10,000 people in the United States. HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is important for physicians to understand the diagnostic strategies in HAE as well as the conventional and emerging therapeutic options available for HAE prophylaxis and acute attacks.
UT Southwestern Medical Center researchers are conducting two pilot clinical trials to determine whether a single, early dose of estrogen can improve survival and neurological outcomes after severe traumatic brain injury or traumatic hemorrhagic shock.
Scurvy is a condition where an individual has a vitamin C (ascorbic acid) deficiency. The name scurvy comes from the Latin scorbutus, and humans have known about the disease since ancient Greek and Egyptian times. Scurvy commonly is associated with sailors in the 16th to 18th centuries who navigated long voyages without enough vitamin C and frequently perished from the condition. Modern cases of scurvy are very rare.
Roll Call reports that "several major industry stakeholders" will be "noticeably absent from the advertising airwaves over the July Fourth recess. Though they will continue to keep in touch with Members through meetings and grass roots, AARP, the American Medical Association, America"s Health Insurance Plans, the Federation of American Hospitals and AdvaMed all say they are sitting out this recess when it comes to advertising campaigns." Senate Finance Chairman Max Baucus, D-Mont., and White House aides have "warned that any groups that run ads attacking reform efforts before the bills have been crafted would lose their seats at the bargaining table," but the "advocacy ad floodgates" may "open shortly." Until then, "groups are working in a lower-profile way to get their messages across to Members," such as planning in-district meetings with Members and activating grassroots networks.
"Major medical organizations are urging health committees in the House and Senate to make comparative-effectiveness research a key component of healthcare reform," Modern HealthCare reports. The Senate Health, Education, Labor and Pension Committee"s bill "plans for a new federal center on health outcomes research was seen by some GOP members as a possible means to ration healthcare." But "a letter, co-signed by the American Medical Association and more than 60 other groups, countered that comparative-effectiveness research would not lead to "cookbook" medicine or rationing of expensive forms of care" (Lubell, 6/26).
Reform Needs Healthy Life Incentives The Wall Street Journal
Newsweek Examines Efforts To Stop Disease Spread By Genetically Modifing Mosquitoes
MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. High levels of miR-196a, a microRNA suppressing the expression of specific homebox genes that are of high relevance for the development of the human embryo, activated oncogenic pathways inside human tumor cells and induced tumor cell dissemination. miR-196a increased the chemosensitivity towards platin derivatives such as cisplatin and oxaliplatin and might be a useful biomarker.
"Although HIV/AIDS continues to pose a serious threat to the nation"s health, HIV testing is a powerful weapon against the disease," Kevin Fenton, director of CDC"s National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, writes in a CNN.com opinion piece. Fenton writes that every 9 1/2 minutes someone in the U.S. becomes infected with HIV. "That"s 56,000 people every year," Fenton writes, adding, "But there"s something we can all do to help protect ourselves and our partners from this disease - get tested for HIV." He continues, "By increasing the number of people who know their HIV status, we can decrease the number of new HIV infections, and help save thousands of lives" (Fenton, CNN.com, 6/26).
New research from the US adds to mounting evidence that when diagnosing bipolar disorder in children doctors and clinicians should consider
"Beware the winter" warn dietitians as research shows more Australians turn to comfort foods at this time of
The recent release of two large randomized trials suggests that if there is a benefit of screening, it is, at best, small, says a new report in CA: A Cancer Journal for Clinicians. Authored by Otis W. Brawley, M.D. of the American Cancer Society and Donna Ankerst, Ph.D. and Ian M. Thompson, M.D. of the University of Texas Health Science Center at San Antonio, the review says because prostate cancer is virtually ubiquitous in men as they age, it is clear that a goal of "finding more cancers" is not acceptable. Instead, public health principles demand that screening must reduce the risk of death from prostate cancer, reduce the suffering from prostate cancer, or reduce health care costs when compared with a non-screening scenario. The authors suggest prostate cancer screening has yet to reach one of these standards to date.
University of Minnesota Medical School researcher Iris Borowsky, M.D., Ph.D., and colleagues found that one in seven adolescents believe that it is highly likely that they will die before age 35, and this belief predicted that the adolescents" would engage in risky behaviors.
Potential new drugs: 970 million and still counting
Every cell lining the small intestine bristles with thousands of tightly packed microvilli that project into the gut lumen, forming a brush border that absorbs nutrients and protects the body from intestinal bacteria. In the June 29, 2009 issue of the Journal of Cell Biology, Matthew McConnell, Matthew Tyska, and colleagues now find that microvilli extend their functional reach even further using a molecular motor to send vesicles packed with gut enzymes out into the lumen to get a head start on breaking down their substrates.
"Epidemiology is always important and topical, though sometimes unsung," says Professor Johan Giesecke, Chief Scientist at ECDC, the European Centre for Disease Prevention and Control, "but the third applied Infectious Disease Epidemiology Conference in Stockholm in October this year will be an opportunity to put Epidemiology and infectious disease prevention and control into the spotlight; delegates will have the opportunity to discuss and share information on current and emerging infectious diseases, including influenza A (H1N1)v. The call for abstracts closes on July 3rd so there is no time to lose."
Ablynx [Euronext Brussels: ABLX], a pioneer in the discovery and development of Nanobodies®, a novel class of antibody-derived therapeutic proteins, announced that it has advanced ALX-0061, a new Nanobody®-based therapeutic programme, into preclinical development for the treatment of autoimmune and inflammatory diseases.
Today, the U.S. Food and Drug Administration announced that it has found E. coli O157:H7 (a bacterium that can cause serious food borne illness) in a sample of prepackaged Nestlç© Toll House refrigerated cookie dough currently under recall by the manufacturer and marketer, Nestlç© USA. The contaminated sample was collected at Nestlç©"s facility in Danville, Va. on June 25, 2009.
New data presented at the British Society for Allergy and Clinical Immunology (BSACI) annual meeting demonstrate that Grazax® is the first tablet treatment to provide sustained disease control in patients with grass pollen rhinoconjunctivitis (hay fever) after the treatment period ended. This is the first time disease modification by sublingual allergy immunotherapy tablets has been achieved; effectively re-setting the immune system to reduce future allergic reactions to grass pollen.
In a study published online by the Journal of Substance Abuse Treatment, UC Davis researchers report that it takes at least a year for former methamphetamine users to regain impulse control. The results tell recovering substance abusers, their families and drug-treatment specialists that it can take an extended period of time for the brain functions critical to recovery to improve.
The July issue of European Urology, the official journal of the European Association of Urology, features an editorial by Lars Holmberg comparing the results from the European Randomised Study of Screening for Prostate Cancer (ERSPC) with the results from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) In the editorial, Professor Holmberg writes that "The studies illustrate that the price to pay for 20% reduction in prostate cancer deaths is high; overdiagnosis and overtreatment are great problems. The answers lie in improving the PSA test or finding biomarkers that effectively separate aggressive cancers from slow-growing ones. We identify some priorities in the discussion about PSA testing."
Enigma Diagnostics Limited, the decentralised and point-of-care molecular diagnostics company, announced successful independent testing for bovine viral diarrhoea (BVD) by the Veterinary Laboratories Agency to evaluate the performance of the Enigma FL (Field Laboratory).
PROLOR Biotech, Inc. (OTC Bulletin Board: PBTH), formerly Modigene Inc., announced that the U. S. Patent and Trademark Office (PTO) has issued two new patents for the company"s long-acting CTP-enhanced human growth hormone (hGH-CTP) and human erythropoietin (EPO-CTP). The patents cover the composition of PROLOR"s proprietary pharmaceutical compounds as well as certain associated methods. PROLOR"s CTP technology is based on a short amino acid sequence, the Carboxyl Terminal Peptide that occurs naturally in humans. When attached to a therapeutic protein, CTP extends the time that the protein is active in the body.
Otitis media, more commonly known as an ear infection, is the most frequently diagnosed illness in children less than 15 years of age in the United States and is the primary cause for emergency room visits. More than 80 percent of children will experience at least one ear infection before their third birthday. Much research has been dedicated to preventing this common childhood disease at Nationwide Children"s Hospital.
Immunology pioneer Professor Chris Goodnow from The Australian National University has been elected as a Fellow of the prestigious UK and Commonwealth academy of science, The Royal Society.
Lower extremity peripheral arterial disease (PAD) affects more than eight million Americans, with significant risks of limb loss, disability and death. Treatment of lower extremity PAD focuses on restoring normal blood supply to the affected limb. Traditional treatment, such as surgical bypass, is effective but invasive. In recent years, many patients have been treated with newer endovascular interventions, using catheter-based devices to reopen peripheral arteries in a less-invasive fashion. According to past research, it is unclear if these newer treatments are as effective as conventional surgical bypass in preventing amputation.
An article published Online First and in a future edition of The Lancet reports on the use of Ketamine as a safe and valuable substitute to conventional etomidate. It is used as a sedative during intubation. Critically ill patients frequently require tubing inserted into their airways to help control their breathing during treatment. The article is the work of Professor Frederic Adnet, SAMU 93, of the Hç´pitaux de Paris, France, and his team.
Plans to scrap some centrally driven targets and proposals for giving doctors and nurses control of their budgets were announced by Health Minister Lord Darzi today.
Applied Genetic Technologies Corporation (AGTC), a privately-held, clinical stage biotechnology company developing novel systems to deliver human therapeutics, announces that AGTC has entered into an agreement with the National Neurovision Research Institute (NNRI), the clinical trial support organization for the Foundation Fighting Blindness(FFB), to collaborate in experiments using the AAV delivery system in the treatment of two genetic retinal diseases known to cause blindness at an early age. The research will be coordinated by AGTC and will be conducted at The University of Florida, Oregon Health & Science University, The University of Pennsylvania, and The University of British Columbia.
PPD, Inc. (NASDAQ: PPDI) today announced that Takeda Pharmaceutical Company Limited issued a news release reporting that Takeda Global Research & Development Center, Inc., its wholly-owned U.S. subsidiary, has received a complete response letter from the U.S. Food and Drug Administration (FDA) regarding its new drug application (NDA) for alogliptin.
The Damon Runyon Cancer Research Foundation named 4 new Damon Runyon Clinical Investigators at its April 2009 Clinical Investigator Award Committee review. The recipients of this prestigious, three-year award are outstanding early career physician-scientists conducting patient-oriented cancer research at major research centers under the mentorship of the nation"s leading scientists and clinicians. Each will receive $450,000 to support the development of his cancer research program.
First Lady Michelle Obama visited a Washington, D.C. community health center Monday afternoon to announce the release of $851 million for the expansion and rehabilitation of clinics around the country, The New York Times reports.
A recent court decision in Black Hawk County, Iowa where a 34-year-old HIV-positive man was sentenced to 25 years in prison and a lifetime of parole for not informing a sexual partner of his status, might lead to a national discussion on state criminal transmission laws, the Iowa Independent reports. Nick Clayton Rhoades pleaded guilty to criminal transmission of HIV, a felony in Iowa, although he did not transmit the virus to his partner. Under state law, "in direct contradiction to its formal title," transmission is not required for a person to be prosecuted - engaging in activity that intentionally exposes others to the body fluids of an infected person could result in prosecution, including kissing, according to the Independent. Some say that such unintended consequences might encourage Iowa and other states to revisit their transmission laws, the article states (Waddington, Iowa Independent, 6/29).
Elsevier, the leading publisher of scientific, technical and medical information, is pleased to announce its renewed publishing partnership with The European Association for the Study of the Liver (EASL), the leading European association in the field of liver research. The agreement calls for Elsevier to publish the society"s flagship journal, the Journal of Hepatology, for the next five years.
Daily sex (or ejaculating daily) for seven days improves men"s sperm quality by reducing the amount of DNA damage, according to an Australian study presented to the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam.
Researchers have found evidence that chronic disease in either a mother or father can create unfavourable conditions in the womb that are associated with the development of polycystic ovarian syndrome (PCOS) in daughters. In another study, researchers found that brothers of women with PCOS and insulin resistance are themselves at greater risk of developing insulin resistance or diabetes, suggesting that factors associated with the condition can be passed down to sons as well as daughters.
Wide gaps in quality outcomes for women persist, not only when compared to men, but among hospitals and states, according to a new study released by HealthGrades, the leading independent healthcare ratings organization. The Sixth Annual HealthGrades Women"s Health in American Hospitals study identifies patient outcomes for maternity care and inhospital treatment of 16 procedures/diagnoses concerning women"s health. Ratings for individual hospitals have been posted at www.healthgrades.com.
Celiac disease, an immune system reaction to gluten in the diet, is over four times more common today than it was 50 years ago, according to findings of a Mayo Clinic study published this month in the journal Gastroenterology.
Developmental hip dysplasia is the most common congenital defect in newborns. The condition occurs when a hip joint is shallow, unstable or when the joint is dislocated. Infants with the condition are often at risk of developing arthritis of the hip as a young adult. A new study published in the July 2009 issue of The Journal of Bone and Joint Surgery (JBJS) finds that screening all infants for hip dysplasia can significantly decrease their chance of developing early arthritis.
The Health and Safety Executive has warned of the danger of not maintaining plant equipment after the death of a telescopic forklift truck driver, who was crushed between the descending arm and side of his vehicle.
Researchers have found that men and women who feel sensitive to rejection based on their physical appearance are more likely to express interest in having cosmetic surgery than those who are less sensitive to appearance-based rejection. This effect is particularly true when people recall negative comments about their physical appearance.
Deputy Executive Director and Chief Operating Officer, Amir Abdulla,
The London Borough of Croydon"s Drug & Alcohol Action Team (DAAT) is using SAS software to achieve better results in its efforts to get more people into drug treatment, reduce drug-related crime and empower the local community to resist drug misuse. SAS, the leader in business analytics software and services, gives the DAAT greater insights to commission services more effectively and target the borough"s res to where they can have the biggest impact. SAS delivers a more "joined-up" approach to allocating treatment across various agencies, which results in the most effective treatment being more quickly assigned to users who really need it.
Many low-income women are failing to take the hormonal therapy prescribed as part of their breast cancer treatment, possibly lowering their survival rates, according to a study led by a researcher in the Duke Comprehensive Cancer Center.
Despite rapid advances using a child"s own cord blood stem cells in regenerative therapies to repair damaged tissue due to injury or disease, most pregnant women today don"t learn about the ability to save their newborn"s cord blood. According to research published in the Journal of Reproductive Medicine, 3 out of every 4 pregnant women consider themselves only "minimally informed."
Adult obesity rates increased in 23 states and did not decrease in a single state in the past year, according to F as in Fat: How Obesity Policies Are Failing in America 2009, a report released today by the Trust for America"s Health (TFAH) and the Robert Wood Johnson Foundation (RWJF). In addition, the percentage of obese or overweight children is at or above 30 percent in 30 states.
A new study of obese adolescents has shown that laparoscopic gastric banding surgery -- the "Lap-Band" procedure -- not only helps them achieve significant weight loss but can also improve and even reverse metabolic syndrome, reducing their risk for cardiovascular disease and diabetes.
Because females carry two copies of the X chromosome to males" one X and one Y, they harbor a potentially toxic double dose of the over 1000 genes that reside on the X chromosome.
On June 11, the National Institute for Health and Clinical Excellence
A study published this week in the open access journal PLoS Medicine finds no evidence to suggest that a controversial antidote recommended by the
There is growing evidence that a procedure for identifying chromosomal abnormalities in embryos prior to in vitro fertilization is ineffective at helping older women become pregnant, the Wall Street Journal reports. The procedure -- known as pre-implantation genetic screening, or PGS -- is performed in dozen of U.S. fertility clinics and sometimes marketed to older women as a way to increase the odds of a healthy live birth. PGS involves extracting a single cell from a six-cell embryo and inspecting it for chromosomal abnormalities known as aneuploidies; unaffected embryos can then be implanted through IVF. Women older than age 35 have a higher risk of aneuploidies, in which embryos have fewer or more than the usual number of 23 pairs of chromosomes. Aneuploidies can trigger early miscarriage or certain genetics conditions, such as Down syndrome. Most medical experts agree that embryo screening is capable of significantly reducing the risk of Down syndrome and other serious chromosome-related illnesses. However, evidence from several studies increasingly suggests that the procedure does not increase older women"s chances of healthy live births. The American Society for Reproductive Medicine released an initial opinion about PGS in 2007, saying that available evidence does not support the use of embryo screening to increase live birth rates in older women. Andrew La Barbera, scientific director of the society, said, "Since that time, there have been several more trials that have reached the same conclusion." Another shortcoming is that most clinics can only test for fewer than half of the 23 chromosomes, meaning that many defects can go undetected. However, medical experts say that the use of PGS has increased in the two years since ASRM issued its recommendations. According to the Journal, PGS can add more than $2,000 to the roughly $10,000 cost of one IVF cycle. Very few health insurers cover PGS, though some pay for IVF. Some experts contend that studies showing a lack of clinical benefit from PGS do not use more efficient biopsy techniques that can prevent damage to the embryo. Santiago Munne, scientific director for Reprogenetics, said that the treatment is "effective." In a 2007 study, Munne and colleagues used PGS to reduce the rate at which patients miscarried. However, the chances of a woman getting pregnant largely were unchanged, which the authors said could be attributed to the small number of study participants (Naik, Wall Street Journal, 6/1).
The drug industry began ramping up its lobbying efforts in 2003, when Medicare Part D began, and now is targeting Democrats.
The 2009 Neuroscience Prize of The Peter and Patricia Gruber Foundation is being awarded to Jeffrey Hall, professor of neurogenetics at the University of Maine; Michael Rosbash, professor and director of the National Center for Behavioral Genomics at Brandeis University; and Michael Young, professor and head of the Laboratory of Genetics at Rockefeller University. On October 18, at the annual meeting of the Society for Neuroscience in Chicago, Illinois, these three distinguished scientists will receive this prestigious international award for their groundbreaking discoveries of the molecular mechanisms that control circadian (daily) rhythms in the nervous system. Their research was the first to establish a simple relationship between single genes and a complex behavior.
Scientists at UC Santa Barbara and several other institutions have found laboratory evidence that a cluster of peptides may be the toxic agent in Alzheimer"s disease. Scientists say the discovery may lead to new drugs for the disease.
GP phone consultations carry definite risks, warns an article in the current edition of Medical and Dental Defence Union of Scotland (MDDUS) magazine Summons today (Thursday, 2 July).
A study in the July 1 issue of the journal SLEEP identified a distinct ECG-derived spectrographic phenotype, designated as narrow-band elevated low frequency coupling (e-LFCNB), that is associated with prevalent hypertension, stroke, greater severity of sleep disordered breathing and sleep fragmentation in patients suffering from obstructive sleep apnea (OSA).
The July issue of Ophthalmology, the journal of the American Academy of Ophthalmology, includes two studies that may influence clinical treatment of serious eye conditions. One study reports on silent cerebral infarcts (SCI) incidence and visual field loss in patients with normal-tension glaucoma; the other correlates inflammation biomarkers with corneal transplant rejection in herpes simplex patients.
A team of Penn State scientists has shed light on the processes that lead to certain human DNA mutations that are implicated in hundreds of inherited diseases such as tuberous sclerosis and neurofibromatosis type 1. The results one day could influence the way couples who seek to have children receive genetic counseling. The team, led by Kateryna Makova, an associate professor of biology, also includes Erika Kvikstad, a graduate student in the Department of Biology, and Francesca Chiaromonte, an associate professor of statistics. Their findings will be published in the July 2009 issue of the journal Genome Research.
Tekmira Pharmaceuticals Corporation (TSX:TKM) announced that it has initiated a Phase 1 human clinical trial for ApoB SNALP. ApoB SNALP, Tekmira"s lead RNAi therapeutic product candidate, is being developed as a treatment for patients with elevated low-density lipoprotein (LDL) cholesterol, or "bad" cholesterol, who are not well served by current therapy. ApoB SNALP is designed to reduce the production of apolipoprotein B (ApoB), a protein produced in the liver that plays a central role in cholesterol metabolism.
Eisai Co., Ltd. (Headquarters: Tokyo, President & CEO: Haruo Naito, "Eisai") and Eisai Corporation of North America (Headquarters: Woodcliff Lake, NJ, Chairman and CEO Hajime Shimizu) are currently focusing on three clinical development programs for the company"s major product Aricept(R) (donepezil hydrochloride tablets) to further contribute to patients with Alzheimer"s disease. As progress in those programs has been made, Eisai announces the status as follows:
The persistent cool and damp weather in the Northeast this spring put many outdoor activities on hold. With the weather finally improving, many people will head outdoors, and when they do, they are likely to find a perennial pest has been lurking, ready to latch onto the next warm-blooded body that comes by. "And that could spell serious health trouble," warns Dr. Chad Richmond, a family physician at the UDMNJ-School of Osteopathic Medicine.
As spectators or players, America"s sports fanatics love ballgames at every age, from kids learning the basics at their first tee-ball game to top athletes playing in the All-Star game. Baseball is a game that can be played throughout our lives if injuries don"t leave us on the sidelines.
PTSD (Post-Traumatic Stress Disorder) is triggered by a traumatic event - it is a kind of anxiety. The sufferer of PTSD may have experienced or seen an event that caused extreme fear, shock and/or a feeling of helplessness. Most of us experience a brief period of difficulty adjusting and coping with traumatic events. However, we gradually get better with time and healthy coping methods. On the other hand, there are times when symptoms get worse and may last for several months, or years. This study explains how PTSD can surface two years after a traumatic event. Another study found that one in eight Lower Manhattan residents likely had PTSD two to three years after the 9/11 attacks.
Tinnitus (from the Latin tinnitus or "ringing") is a condition characterized by ringing, swishing, or other noises that appear to be originating in the ear or head. Not normally a dangerous or serious problem, tinnitus is usually a symptom of some other underlying condition and most often considered a nuisance. Age-related hearing loss, ear injury, foreign objects in the ear, and circulatory system problems, for example, may cause the condition.
This statement updates Members on the Influenza A (H1N1) swine flu outbreak and the latest developments in Wales, across the UK and internationally.
As President Barack Obama calls for streamlining heath care by fully converting to electronic medical records and as Congress prepares to debate issues of patient privacy, one question has largely gone unasked: What do patients want?
A lack of emotional intelligence leads to poor coping strategies and seriously increases the likelihood of self-harm in teenagers, claims a study published yesterday, in the British Journal of Clinical Psychology.
Sen. Charles Schumer, D-N.Y., a member of the key Senate Finance Committee and advocate for a government-run health insurance plan, said yesterday he would abandon all other possible compromises in favor of immediately creating a public plan that "would operate on "a level playing field" with private insurers," CongressDaily reports. Other proposals have included a plan that would establish health insurance co-ops with government seed money or "trigger" the creation of a public plan only if private insurers fail to meet certain targets for containing costs and improving access.
"A new large-scale study of medical records found that the extra cost of extending prescription coverage to Medicare enrollees was substantially offset by lower spending on other medical care for people who previously had limited or no prescription-drug coverage," The Wall Street Journal reports.
"The Food and Drug Administration announced (Wednesday) that it is requiring the smoking-cessation drugs Chantix and Zyban to carry the strongest type of safety warning possible to alert patients that the medications can cause serious mental health problems, including depression and suicide," the Washington Post reports (Stein, 7/1).
The following summarizes news coverage of state abortion statistics in Minnesota and Wisconsin.~ Minnesota: The number of abortions performed in Minnesota decreased for the second consecutive year in 2008, according to an annual report from the state Department of Health, the Minneapolis Star Tribune reports. Except for a one-time increase in 2006, the number of abortions in Minnesota has trended downward since a peak in 1980, when 19,028 procedures were performed. The new report found that 12,948 abortions were performed in the state in 2008, a decrease of 895 from 2007. Women ages 20 to 24 accounted for about one-third of the procedures, the most among any age group. The number of procedures among teenagers continued a decline that began in the 1990s but had leveled off slightly earlier this decade, the report found. The report also found that less than one-third of women reported using contraception and about one in seven was married at the time of conception (Von Sternberg, Minneapolis Star Tribune, 7/1).~ Wisconsin: Wisconsin abortion providers performed 8,229 procedures in 2008, the lowest number since the state began collecting statistics in 1974, according to an annual report by the state Department of Health Services, the AP/Milwaukee Journal-Sentinel reports. The number of abortions has declined annually since 2003, when 10,557 procedures were performed. State law requires abortion providers to provide DHS with the data. According to the report, slightly more than half of abortions took place in the first eight weeks of pregnancy. Women who had never been married accounted for about three-fourths of all procedures. The report found that 12% of abortions occurred among women ages 35 and older; 34% were among women ages 20 to 24; 11% were among women ages 18 and 19; and 6% were among girls ages 15 to 17. The number of abortions among minors decreased from 551 in 2007 to 500 in 2008, with parents providing consent in 452 of those cases (Richmond, AP/Milwaukee Journal-Sentinel, 6/30).
The British Psychological Society"s Division of Clinical Psychology has welcomed Lord Layard"s call for 1,000 more child therapists to be employed by the NHS to improve access to evidence-based psychological interventions for children.
The NPA is working with LPCs and PCTs to develop a process for assuring the quality of commissioning of community pharmacy services. The aim of the project is to increase constructive dialogue between contractors and commissioners, increase the level of local investment in pharmacy services and improve PCT performance right the way around the commissioning cycle.
The American Society of Radiologic Technologists announced it has released the first in a series of interactive learning modules focusing on computed tomography. CT Basics: Module 1 - Fundamentals provides in-depth information about the modality and its equipment and also offers radiologic technologists information about careers in CT. The first of 10 modules, the program features colorful images with easy-to-understand animations that engage participants in the learning process.