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Popular Articles

University Of Central Lancashire To Deliver Nurtured Heart Workshop, UK
Residential childcare and fostering agency, Perpetual Care, and the University of Central Lancashire"s School of Nursing & Caring Sciences are jointly developing an introductory workshop on the ground-breaking Nurtured Heart Approach, which seeks to improve social and educational outcomes for many children and young people. Experts from UCLan and Perpetual are currently designing an awareness workshop, which will provide an overview of the approach, examine existing US research findings and explore its potential role in UK residential childcare and fostering, particularly in the light of revised NICE guidelines relating to children with ADHD. The first session is scheduled at UCLan"s Preston campus in late June this year and should be of interest to registered social workers, local authority placement officers and other social care and health professionals concerned with the well-being of challenging young people.

Kaiser Permanente Project Proves Electronic Health Information And Care Coordination Improve Chronic Disease Management
Specialty care physicians can improve the health of high-risk patients by reviewing electronic health records and proactively providing e-consultations and treatment plan recommendations with primary care physicians, according to a Kaiser Permanente paper published online in the British Medical Journal.
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Drug & Alcohol Action Team Uses SAS To Tackle Drugs And Save Lives By Improving Joined-Up Delivery
The London Borough of Croydon"s Drug & Alcohol Action Team (DAAT) is using SAS software to achieve better results in its efforts to get more people into drug treatment, reduce drug-related crime and empower the local community to resist drug misuse. SAS, the leader in business analytics software and services, gives the DAAT greater insights to commission services more effectively and target the borough"s res to where they can have the biggest impact. SAS delivers a more "joined-up" approach to allocating treatment across various agencies, which results in the most effective treatment being more quickly assigned to users who really need it.
Diagnostics

Reprogrammed Mouse Fibroblasts Can Make A Whole Mouse

In a paper publishing online July 23 in Cell Stem Cell, a Cell Press journal, Dr. Shaorong Gao and colleagues from the National Institute of Biological Sciences in Beijing, China, report an important advance in the characterization of reprogrammed induced pluripotent stem cells, or iPSCs. Scientists working with iPSCs have been eager to find out if these cells are fully pluripotent, as this would tell us to what extent they have in fact been truly reprogrammed and resemble normal embryonic stem cells (ESCs). The generally accepted "gold standard" for determining whether a mouse iPSC line has been fully reprogrammed is to show that when injected into an early embryo (or blastocyst), the iPSCs can contribute to many different tissues in the resulting chimeric mouse, including the germline. However, unlike bona fide mouse ESCs, until now mouse iPSCs have not been able to pass a more stringent test of true pluripotency termed "tetraploid complementation," which uses a hybrid embryo method to generate full-term mice entirely comprised of ESC-derived cells. In their current report, Gao and his colleagues used established methods to reprogram mouse cells to isolate five new iPSC lines, and then found that, using one of these lines, they were able to make by tetraploid complementation embryos that survived until birth, and one embryo that also survived to adulthood. The authors decided to test this specific iPSC line in the tetraploid complementation experiment because it gave an unusually high level of chimerism when injected into blastocysts and thus might have unique characteristics not found in many other iPSC lines. As emphasized by Gao, "Although these findings are an important proof of principle, it would be premature to make claims about whether iPSCs in general are functionally equivalent to normal ESCs." As the authors remark in their paper, it will be interesting to determine if there are specific reasons why this particular line succeeded where others have failed. The demonstration that mouse iPSCs can, in fact, pass the most stringent test of pluripotency offers added hope that the process of reprogramming may indeed one day overcome the need for embryo destruction in order to derive pluripotent cells for research and potential therapies. However, it remains to be seen whether lessons obtained from these findings can be applied to human cells and thus whether human iPSCs will be a viable alternative to human ESCs in all circumstances. The authors include Lan Kang, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, National Institute of Biological Sciences, Beijing, China; Jianle Wang, National Institute of Biological Sciences, Beijing, China; Yu Zhang, National Institute of Biological Sciences, Beijing, China; Zhaohui Kou, National Institute of Biological Sciences, Beijing, China; and Shaorong Gao, National Institute of Biological Sciences, Beijing, China. Cathleen Genova Cell Press


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