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Crohn's Disease: Case Western Reserve Researchers Identify Links Between Inflammatory Disease Genes
Researchers from Case Western Reserve University School of Medicine identified a novel link between ITCH, a gene known to regulate inflammation in the body and NOD2, a gene which causes the majority of genetic Crohn"s Disease diagnoses. ITCH, when malfunctioning, causes widespread inflammatory diseases, including inflammatory bowel disease, gastritis, uncontrolled skin inflammation, and pulmonary pneumonitis. Derek Abbott, M.D., Ph.D., and his team of researchers found that ITCH also influences NOD2-induced inflammation. These findings, published in the August 11th issue of Current Biology, suggest a common pathophysiology exists between multiple inflammatory diseases. The unexpected finding of the interaction between these genes offers the possibility of a new drug target, which would be effective in treating Crohn"s disease - a chronic disorder causing inflammation of the gastrointestinal tract.
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Hospital Rankings Released By U.S. News And World Report
"This is Year 20 for America"s Best Hospitals, a tool for patients who need medical sophistication that most facilities are unable to provide," reports U.S. News and World Report. The magazine ranked hospitals based on how well they did in "complex and demanding situations" such as "replacing an 85-year-old"s heart valve, diagnosing and treating a spinal tumor, and dealing with inflammatory bowel disease." Out of a total 4,861 hospitals analyzed, "Only 174 hospitals scored high enough to be ranked in even one of the 16 specialties. And of these, just 21 qualified for [the] Honor Roll by ranking at or near the top in at least six specialties." The ranking list includes the 50 highest scoring hospitals (Comarow, 7/15).
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New York Times Examines Debate Surrounding Use Of Experimental Treatments In Terminally Ill Patients
Some patient advocates are lobbying to legalize "compassionate use" of experimental drugs for people with terminal illnesses who have exhausted other treatments, prompting a debate about how and when to provide such patients with treatments that could prolong their lives, the New York Times reports. Most insurers do not cover unproven treatments, and physicians have concerns that using experimental treatment could give patients false hope and cause unnecessary pain. Drugmakers are concerned that if there are unfavorable outcomes from providing patients with an unproven treatment, it could hurt the drug"s chances of receiving FDA approval. At the same time, FDA does not want to grant drugs and their makers the opportunity to skip clinical trials. Currently, patients must individually apply to receive treatments through compassionate use (Harmon, New York Times, 5/17).
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Over Half Of People With Rheumatoid Arthritis Have Periodontitis

Over half (56%) of people with rheumatoid arthritis (RA) also have periodontitis (a chronic inflammatory disease of the gum and surrounding ligaments and bones that hold the teeth in place), displaying fewer teeth than healthy matched controls, high prevalence of oral sites presenting dental plaque and advanced attachment loss (the extent of periodontal support that has been destroyed around a tooth) (chi square p


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