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CNN Examines Efforts To Prevent Nursing Shortages In Malawi
CNN examines Malawi"s efforts to address its shortage of nurses. Though in the past, health workers "have been lured abroad by the promise of higher wages and better working conditions," the country has succeeded in putting a stop to "its crippling brain drain of nurses" by expanding "educational opportunities for nurses at all levels" and by "paying modestly more money," CNN writes.

AARP On Medicare Trustees Report: "Medicare's Accelerating Insolvency. Will Only Be Fixed By Comprehensive Reform In 2009."
AARP Executive Vice President John Rother issued the
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Proposed California Budget Cuts To State HIV/AIDS Programs Will 'Cost Lives', Opinion Piece Says
"California will not be saving money," in its proposal to cut funding from HIV/AIDS programs, including the state AIDS Drug Assistance Program, Ken Owens, member of the Inland Empire HIV Planning Council and former member of the Desert AIDS Client Committee, writes in a Desert Sun opinion piece. He adds, "Instead, it will have more people looking for places to live and needing more state services because they are sick, need welfare funds and state healthcare." Owens continues, "Their plan of balancing the budget will surely cost lives if HIV/AIDS funding is cut" (Owens, Desert Sun, 6/18).
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New Malaria Vaccine Approach To Be Tested By PATH Malaria Vaccine Initiative And Crucell

The US-based PATH Malaria Vaccine Initiative (MVI), the United States Agency for International Development (USAID) Malaria Vaccine Development Program (MVDP), and Dutch biopharmaceutical company Crucell N.V. today announced a collaboration to accelerate development of a promising type of malaria vaccine. Through funding from the USAID MVDP, the partners will conduct studies to determine the effectiveness of Crucell"s novel prime-boost vaccine approach against the malaria parasite, Plasmodium falciparum. This approach uses Crucell"s proprietary recombinant adenoviruses (a type of virus associated with the common cold and other mild respiratory infections) to deliver a malaria antigen to the immune system. Dr. Jaap Goudsmit, Chief Scientific Officer at Crucell, commented, "This agreement is a strong validation of Crucell"s malaria vaccine approach. We are excited to have MVI as our partner and to have the support of USAID. The fact that MVI is backing our program testifies to the importance of our efforts to further progress the development of Crucell"s malaria vaccine." For MVI, this partnership adds to its existing portfolio a vaccine approach with the potential to elicit a more comprehensive immune response than has been seen to date from the circumsporozoite protein (CSP), the only antigen that has proven to be protective against malaria in controlled challenge studies and field studies. Using Crucell"s AdVac technology with two different vectors - the adenovirus serotypes Ad35 and Ad26 - as delivery mechanisms, this approach seeks to elicit a protective immune response obtained from delivering the CSP. The safety, immunogenicity and efficacy data from these studies will further advance the research forward development of a safe and highly efficacious malaria vaccine. "Adenoviruses are one of the most potent vaccine delivery systems tested to date in humans. We are excited about the potential of Crucell"s adenovirus-based program and the novel Ad35/Ad26 approach. The prime-boost regimen may be a critical next step in malaria vaccine development and, if successful, could move us toward our goal of having an 80 percent efficacious vaccine in use by 2025," said MVI Director, Dr. Christian Loucq. Crucell is developing a recombinant malaria vaccine, Ad35-CS, based on the company"s AdVac technology and PER.C6 manufacturing platform. The vaccine candidate is made by inserting the CSP gene from the P. falciparum malaria parasite into adenoviral vectors, which act as a "vehicle" for vaccination delivery. This prime vaccine candidate is currently being tested in a Phase 1 study in partnership with the National Institute of Allergy and Infectious Diseases. This new collaboration will make it possible to clinically develop the Ad26 boost component of the vaccine and allow Crucell to further strengthen and expedite its malaria development program. Carter Diggs at the USAID MVDP said, "We are pleased to support this adenovirus approach, which could play a vital role in malaria vaccine development." Preeti Singh Burness Communications


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