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Recognizing 'Intoxication'
One well-known and often deadly consequence of alcohol intoxication is impaired driving. Yet still today, it is difficult for even trained observers to fully identify "intoxication," given that so many factors contribute to it. This review examines the very definition of intoxication, as well as methods designed to prevent impaired driving.

Tekmira Pharmaceuticals Initiates ApoB SNALP Phase 1 Clinical Trial
Tekmira Pharmaceuticals Corporation (TSX:TKM) announced that it has initiated a Phase 1 human clinical trial for ApoB SNALP. ApoB SNALP, Tekmira"s lead RNAi therapeutic product candidate, is being developed as a treatment for patients with elevated low-density lipoprotein (LDL) cholesterol, or "bad" cholesterol, who are not well served by current therapy. ApoB SNALP is designed to reduce the production of apolipoprotein B (ApoB), a protein produced in the liver that plays a central role in cholesterol metabolism.
News of the day
British Medical Association Cymru Wales Launches The 'Option 7' Campaign - To Improve The Lives Of Junior Doctors
BMA Cymru Wales on Monday launched a campaign aimed at improving the working lives of junior doctors in Wales.
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May Developmental Experiences Explain "unexplained" Medical Symptoms?

A new theory on the role of developmental experiences is presented in the current issue of Psychotherapy and Psycosomatics. Medically unexplained (or "functional") symptoms (MUS) are physical symptoms that prompt the sufferer to seek healthcare but remain unexplained after an appropriate medical evaluation. Examples of MUS also occur in veterinary medicine. For example, domestic cats suffer a syndrome comparable to interstitial cystitis, a chronic pelvic pain syndrome of humans. Review of current evidence suggests the hypothesis that developmental factors may play a role in some cases of MUS. Maternal perception of a threatening environment may be transmitted to the fetus when hormones cross the placenta and affect fetal physiology, effectively "programming" the fetal stress response system and associated behaviors toward enhanced vigilance. After birth, intense stress responses in the individual may result in similar vulnerability, which may be unmasked by subsequent stressors. Epigenetic modulation of gene expression (EMGEX) appears to play a central role in creation of this "survival phenotype". The recent development of techniques to identify the presence of EMGEX provides new tools to investigate these questions, and drugs and other interventions that may reverse EMGEX are also under active investigation. Psychotherapy and Psychosomatics


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