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Bladder Cancer - Molecular Analyte Profiling Of Early Events & Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy
UroToday.com - Since the work of Morales et al. in 1976, BCG therapy has been the standard of care for superficial transitional cell carcinoma. Although it has been shown that BCG instillations triggers Th1-mediated responses in patients, the precise mechanism(s) leading to the observed anti-tumoral response remain(s) unknown. More importantly, there are currently defined biomarkers for monitoring the response to BCG. This is particularly relevant as 30-40% of the patients fail to respond to intravesical therapy or relapse within the 5 years. In our recently published study, we investigated the molecular and cytometric profile of the immune response of 17 patients undergoing BCG therapy, and provide the first systemic evaluation of the innate response to intravesical BCG.

Special Reconstruction Method Improves Postoperative Quality Of Life In Gastric Cancer Patients
Given equivalent results with regards to survival, the impact of anastomotic methods on QOL becomes even more important. There is still no consensus on how to choose a reconstruction method for proximal gastrectomy in patients with upper third gastric cancer.
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CEL-SCI Files Patent Application To Support Company's Treatment For More Virulent Strain Of H1N1 Swine And Other Influenza Viruses
CEL-SCI CORPORATION (NYSE AMEX: CVM) announced that it has filed a provisional U.S. patent application covering its L.E.A.P.S.(TM) immune therapy drugs (vaccines) for the prevention/treatment of H1N1, swine, bird flu, Influenza A and/or evolving mutants or variants of these viruses. Some experts believe that by the next flu season the swine flu virus will have evolved and/or combined with other viruses to create a much more lethal new virus. That is what happened in the case of the Spanish flu pandemic. CEL-SCI"s efforts to fight this virus are focused on using conserved epitopes from essential proteins to be found in the A influenza virus for H1N1, H1N5, swine, bird flu and Spanish influenza to create an effective vaccine/treatment that could potentially fight such a mutant virus.
Oncology

Leading Authority On Alzheimer's Disease To Present At Community Lecture

Jason Karlawish, M.D., associate professor of medicine, University of Pennsylvania, will share the latest information on Alzheimer"s disease at a community lecture at 1 p.m., Wednesday, June 10 at Rodef Shalom Congregation, 4905 Fifth Ave., Shadyside. The event is free and open to the public. Part of the Jay L. Foster Memorial Lecture in Alzheimer"s disease, Dr. Karlawish"s talk, "The Making and Unmaking of Alzheimer"s Disease," will focus on the quality of life and treatment challenges the disease poses to society, families and patients. The lecture series was established by the family of Jay L. Foster, a Pittsburgh businessman who died from the disease in 2000, and aims to offer support and information for family members, caregivers and others who face the daily struggle of dealing with Alzheimer"s. Dr. Karlawish, director of education, recruitment and retention at the Alzheimer"s Disease Center at Penn, is an expert on medical decision making and research ethics related to memory disorders. He is a member of the ethics committees of the American Geriatrics Society and the Alzheimer"s Disease Cooperative Study Group. He has published numerous studies on competency and dementia care, and received many awards for his work, including the Greenwall Foundation Faculty Scholarship in Bioethics and the Lancet"s Wakley prize. Following the lecture, faculty and staff from the University of Pittsburgh Alzheimer"s Disease Research Center and Pitt"s Graduate School of Public Health"s Center for Healthy Aging will comment and answer audience questions. The Foster family established the lecture series after learning firsthand that knowledge about Alzheimer"s disease is an important factor in coping with its effects on the family, especially the pain of watching a loved one decline. They hope that caregivers, family members, residential treatment staff and other health professionals will be aided by the talks, which are managed by GSPH through the support of the Foster Charitable Trust. University of Pittsburgh


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