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Evidence Challenges Effectiveness Of Embryo Screening For Older Women
There is growing evidence that a procedure for identifying chromosomal abnormalities in embryos prior to in vitro fertilization is ineffective at helping older women become pregnant, the Wall Street Journal reports. The procedure -- known as pre-implantation genetic screening, or PGS -- is performed in dozen of U.S. fertility clinics and sometimes marketed to older women as a way to increase the odds of a healthy live birth. PGS involves extracting a single cell from a six-cell embryo and inspecting it for chromosomal abnormalities known as aneuploidies; unaffected embryos can then be implanted through IVF. Women older than age 35 have a higher risk of aneuploidies, in which embryos have fewer or more than the usual number of 23 pairs of chromosomes. Aneuploidies can trigger early miscarriage or certain genetics conditions, such as Down syndrome. Most medical experts agree that embryo screening is capable of significantly reducing the risk of Down syndrome and other serious chromosome-related illnesses. However, evidence from several studies increasingly suggests that the procedure does not increase older women"s chances of healthy live births. The American Society for Reproductive Medicine released an initial opinion about PGS in 2007, saying that available evidence does not support the use of embryo screening to increase live birth rates in older women. Andrew La Barbera, scientific director of the society, said, "Since that time, there have been several more trials that have reached the same conclusion." Another shortcoming is that most clinics can only test for fewer than half of the 23 chromosomes, meaning that many defects can go undetected. However, medical experts say that the use of PGS has increased in the two years since ASRM issued its recommendations. According to the Journal, PGS can add more than $2,000 to the roughly $10,000 cost of one IVF cycle. Very few health insurers cover PGS, though some pay for IVF. Some experts contend that studies showing a lack of clinical benefit from PGS do not use more efficient biopsy techniques that can prevent damage to the embryo. Santiago Munne, scientific director for Reprogenetics, said that the treatment is "effective." In a 2007 study, Munne and colleagues used PGS to reduce the rate at which patients miscarried. However, the chances of a woman getting pregnant largely were unchanged, which the authors said could be attributed to the small number of study participants (Naik, Wall Street Journal, 6/1).
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JDRF Launches Innovative Cure Collaboration Partnership With Sanford Health
The Juvenile Diabetes Research Foundation International, the world"s leading charitable funder and advocate of diabetes research, said that it is partnering with Sanford Health, an integrated health care system in South Dakota and the Midwest, in an innovative "cure collaboration" to speed the pace of diabetes research and delivery of cures at the point-of-care.
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Anti-Epilepsy Drug Risk On Cognitive Function For Unborn Children
Interim results of a study being conducted by scientists at the University of Liverpool suggest that children aged three years and younger, who are born to women taking the anti-epileptic drug sodium valproate whilst pregnant, are likely to have an IQ of six to nine points lower than average.
Cardiovascular

Illinois Counties Facing Increases In STDs Among Teenagers; Bill Aims To Reduce Rates

Illinois health officials contend that images seen in the media, social influences, and a lack of "frank" discussion on STDs in schools, among other issues, might be contributing to increases in STD rates across the state, the State Journal-Register reports. "According to recently released data, new cases of chlamydia in Illinois reached an all-time high statewide in 2008 - 59,169 - while the number of gonorrhea cases outside Chicago has been rising in recent years and totaled 10,165 in 2008," the Journal-Register reports. In addition, about 35,000 state residents have HIV/AIDS, the article states. Charlie Rabins, chief of the STD program at the Illinois Department of Public Health, said a bill (SB 212) currently awaiting Gov. Pat Quinn"s (D) approval might help reduce STD rates. The bill "would allow what is called "expedited partner therapy," in which medical professionals who treat patients for gonorrhea or chlamydia can give those patients single-dose antibiotics to pass on to sexual partners without first examining the partners," according to the Journal-Register (Olsen, 7/27). This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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