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Extending The Life Of An Appetite-Suppressing Peptide
The peptide alpha-MSH works in a region of the brain known as the hypothalamus to suppress appetite. A team of researchers, at Yale University School of Medicine, New Haven, and the University of California Davis, has provided new insight into the way in which levels of the active form of alpha-MSH are regulated in mice. Specifically, genetic and biochemical analysis performed by the team, led by Sabrina Diano and Craig Warden, indicated that the protein PRCP is expressed in the hypothalamus and breaks down the active form of alpha-MSH, generating a slightly smaller peptide that does not suppress food intake. Importantly, administration of PRCP inhibitors to both normal and obese mice reduced their food intake. Further, mice lacking PRCP had increased levels of the active form of alpha-MSH in the hypothalamus and were leaner and shorter than normal mice; they also did not get obese when fed a high-fat diet. The authors suggest that these data are the first step in identifying PRCP as a candidate drug target for the treatment of obesity and obesity-related disorders. Although Richard Palmiter, at the University of Washington, Seattle, also raises this intriguing possibility, he cautions that any drug would need to penetrate the brain.
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Leading Authority On Alzheimer's Disease To Present At Community Lecture
Jason Karlawish, M.D., associate professor of medicine, University of Pennsylvania, will share the latest information on Alzheimer"s disease at a community lecture at 1 p.m., Wednesday, June 10 at Rodef Shalom Congregation, 4905 Fifth Ave., Shadyside. The event is free and open to the public.
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Northeast Colorado Conference Discusses HIV/AIDS Needs Assessment Findings
Rural Solutions, an organization in northeast Colorado, held the "Community HIV/AIDS Education and Action Conference" as part of its ongoing effort to address issues related to HIV, the Sterling Journal-Advocate reports. At the conference, the organization presented the results of a recent needs assessment of HIV/AIDS services in the northeastern part of the state - conducted in partnership with the Center for Research Strategies and funded through the Colorado Department of Public Health and Environment - which found that HIV prevention services in the area are limited; barriers exist for HIV testing including confidentiality and costs; and mental health and substance use services for at-risk people also are limited, according to the Journal-Advocate (Jones, Sterling Journal-Advocate, 6/17).
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Drug & Alcohol Action Team Uses SAS To Tackle Drugs And Save Lives By Improving Joined-Up Delivery

The London Borough of Croydon"s Drug & Alcohol Action Team (DAAT) is using SAS software to achieve better results in its efforts to get more people into drug treatment, reduce drug-related crime and empower the local community to resist drug misuse. SAS, the leader in business analytics software and services, gives the DAAT greater insights to commission services more effectively and target the borough"s res to where they can have the biggest impact. SAS delivers a more "joined-up" approach to allocating treatment across various agencies, which results in the most effective treatment being more quickly assigned to users who really need it. A multi-agency public sector partnership, Croydon"s DAAT, unites representatives from the local council, health service, police and criminal justice system and the voluntary sector. SAS" software helps the DAAT to plan treatment modernisation services that deliver effective treatment structures for substance misuse and ensures that the work of local agencies and cross-agency projects are integrated successfully. SAS software also helps the DAAT to automate statutory "Green Reports" for the National Drug Treatment Monitoring System as well as key performance indicator (KPI) reporting against national Home Office targets, which improves operational effectiveness at a local level by cutting administration time from over a week down to half a day. With SAS, the DAAT can perform analysis in line with national KPIs for drug treatments, monitor the local agencies" performances and explore new ways to deliver improved treatment structures within their very tight budgets. Says Ray Rajagopalan, Data Manager at Croydon"s DAAT: "By using SAS, we can analyse the success and failure of specific treatment programmes and see whether our treatment structure actually meets the needs of the local population. SAS saves us time by being able to immediately detect weaknesses in the system rather than waiting a year or more before an issue becomes apparent. Having that ability to pre-empt problems and to do things at a much quicker pace enables early indicators to be identified and corrective action to be taken far sooner in the reporting cycle. SAS software enables DAAT decision-makers to get on with sorting problems out, making changes and re-allocating res, to improve the local treatment system and provide more effective front-line services." Before SAS, the DAAT used basic spreadsheet tools such as Microsoft Excel and Access, which were unable to manage its growing volumes of data or quickly provide the comprehensive analysis needed. Rajagopalan continues: "Having proper analytics from SAS provides us with a range of benefits that we never had before. It is improving the time scales required to produce comprehensive analysis." Ian Manocha, Managing Director of SAS UK, states: "It"s an honour for SAS to be an integral part of the DAAT process in tackling drugs and ultimately saving lives. It"s great to see that our strength in analytics can help apply res in the best way and change the lives of real people for the better." SAS


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